Open AccessGenetic Variation in the Scavenger Receptor MARCO and Its Association with Chronic Obstructive Pulmonary Disease and Lung Infection in 10,604 Individuals
Author(s) -
M Thomsen,
Børge G. Nordestgaard,
Lester Kobzik,
Morten Dahl
Publication year - 2012
Publication title -
respiration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.264
H-Index - 81
eISSN - 1423-0356
pISSN - 0025-7931
DOI - 10.1159/000342354
Subject(s) - medicine , copd , odds ratio , lung , population , obstructive lung disease , cohort , genotype , immunology , genetics , biology , gene , environmental health
MARCO (macrophage receptor with collagenous structure) is a dominant receptor for unopsonized particles and bacteria in the lungs. Reduced function of this receptor due to genetic variation may be associated with susceptibility to chronic obstructive pulmonary disease (COPD) and lung infection.