Open AccessUbiquitin E3 Ligase A20 Contributes to Maintaining Epithelial Barrier Function
Author(s) -
Peixin Huang,
Xinyu Geng,
Gui Yang,
Chi Chen,
Zhanju Liu,
PingChang Yang
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000341450
Subject(s) - microbiology and biotechnology , endosome , endocytic cycle , endocytosis , barrier function , lysosome , ubiquitin ligase , ubiquitin , biology , chemistry , cell , intracellular , biochemistry , gene , enzyme
Epithelial barrier dysfunction is involved in the pathogenesis of allergic diseases; the mechanism is to be further understood. Ubiquitin E3 ligase A20 (A20) plays a role in maintaining the homeostasis in the body. This study aims to investigate the role of A20 in maintaining the epithelial barrier function.