Open AccessIn vivoElectrophysiological Characterization of TASK-1 Deficient Mice
Author(s) -
Stella Petric,
Lukas Clasen,
Carina van Weßel,
Nora Geduldig,
Zhaoping Ding,
Martina Schullenberg,
Jan Mersmann,
Kai Zacharowski,
M. Isabel Aller,
Klaus G. Schmidt,
Birgit Donner
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000341435
Subject(s) - electrophysiology , in vivo , biology , neuroscience , medicine , genetics
TASK-1 is a potassium channel predominantly expressed in heart and brain. We have previously shown that anesthetized TASK-1(-/-)mice have prolonged QT intervals in surface electrocardiograms (ECGs). In addition, heart rate variability quantified by time and frequency domain parameters was significantly altered in TASK-1(-/-) mice with a sympathetic preponderance. Aims of the present study were the analysis of QT intervals by telemetric ECGs, to determine potential influences of anesthesia and β-adrenergic stimulation on repolarization in surface ECGs, to investigate in vivo electrophysiological parameters by intracardiac electrical stimulation and to quantify heart rate turbulence after ischemia/reperfusion or ventricular pacing in TASK-1(+/+) and TASK-1(-/-) mice.