In vivoElectrophysiological Characterization of TASK-1 Deficient Mice | Zendy

Stella Petric | Zendy; Lukas Clasen | Zendy; Carina van Weßel | Zendy; Nora Geduldig | Zendy; Zhaoping Ding | Zendy; Martina Schullenberg | Zendy; Jan Mersmann | Zendy; Kai Zacharowski | Zendy; M. Isabel Aller | Zendy; Klaus G. Schmidt | Zendy; Birgit Donner | Zendy

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In vivoElectrophysiological Characterization of TASK-1 Deficient Mice

Author(s) -

Stella Petric,

Lukas Clasen,

Carina van Weßel,

Nora Geduldig,

Zhaoping Ding,

Martina Schullenberg,

Jan Mersmann,

Kai Zacharowski,

M. Isabel Aller,

Klaus G. Schmidt,

Birgit Donner

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000341435

Subject(s) - electrophysiology , in vivo , biology , neuroscience , medicine , genetics

TASK-1 is a potassium channel predominantly expressed in heart and brain. We have previously shown that anesthetized TASK-1(-/-)mice have prolonged QT intervals in surface electrocardiograms (ECGs). In addition, heart rate variability quantified by time and frequency domain parameters was significantly altered in TASK-1(-/-) mice with a sympathetic preponderance. Aims of the present study were the analysis of QT intervals by telemetric ECGs, to determine potential influences of anesthesia and β-adrenergic stimulation on repolarization in surface ECGs, to investigate in vivo electrophysiological parameters by intracardiac electrical stimulation and to quantify heart rate turbulence after ischemia/reperfusion or ventricular pacing in TASK-1(+/+) and TASK-1(-/-) mice.

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