Open AccessIschemia and Reperfusion Liver Injury is Reduced in the Absence of Toll-like Receptor 4
Author(s) -
Ziv BenAri,
Orna Avlas,
Reut Fallach,
Hemda SchmilovitzWeiss,
Yelena Chepurko,
Orit Pappo,
Edith Hochhauser
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000341432
Subject(s) - reperfusion injury , toll like receptor , receptor , ischemia , medicine , innate immune system
Toll-like receptor 4 (TLR4) is expressed on hepatic non-parenchymal cells and hepatocytes. Hepatic signaling through TLR4 is critical in the pathogenesis of ischemia reperfusion injury (IRI) and leads to the release of cytokines. The role of bone marrow-derived TLR4 in the early reperfusion stage is unclear.