Open AccessGenomic and Metabolic Responses to Methionine-Restricted and Methionine-Restricted, Cysteine-Supplemented Diets in Fischer 344 Rat Inguinal Adipose Tissue, Liver and Quadriceps Muscle
Author(s) -
Carmen E. Perrone,
Dwight A.L. Mattocks,
Jason D. Plummer,
Sridar V. Chittur,
Rob P. Mohney,
Katie S. Vignola,
David S. Orentreich,
Norman Orentreich
Publication year - 2012
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000339347
Subject(s) - methionine , adipose tissue , cysteine , muscle tissue , endocrinology , medicine , biology , white adipose tissue , biochemistry , amino acid , enzyme
Methionine restriction (MR) is a dietary intervention that increases lifespan, reduces adiposity and improves insulin sensitivity. These effects are reversed by supplementation of the MR diet with cysteine (MRC). Genomic and metabolomic studies were conducted to identify potential mechanisms by which MR induces favorable metabolic effects, and that are reversed by cysteine supplementation.