Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity | Zendy

Tina Sartorius | Zendy; Martin Heni | Zendy; Otto Tschritter | Zendy; Hubert Preißl | Zendy; Sabine Hopp | Zendy; Andreas Fritsche | Zendy; Paul-Simon Lievertz | Zendy; Arieh Gertler | Zendy; Flavien Berthou | Zendy; Mohammed Taouis | Zendy; Harald Staiger | Zendy; HansUlrich Häring | Zendy; Anita M. Hennige | Zendy

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Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity

Author(s) -

Tina Sartorius,

Martin Heni,

Otto Tschritter,

Hubert Preißl,

Sabine Hopp,

Andreas Fritsche,

Paul-Simon Lievertz,

Arieh Gertler,

Flavien Berthou,

Mohammed Taouis,

Harald Staiger,

HansUlrich Häring,

Anita M. Hennige

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000339060

Subject(s) - insulin , medicine , endocrinology , leptin , insulin receptor , leptin receptor , diabetes mellitus , insulin receptor substrate , irs1 , glycogen synthase , insulin resistance , biology , obesity

Impaired insulin action is an early event in the pathogenesis of obesity and type 2-diabetes, and among the metabolic confounders in obese, hyperleptinaemia is constantly present; however its impact on insulin action in the brain and locomotor activity is unknown.

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