Open AccessLeptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity
Author(s) -
Tina Sartorius,
Martin Heni,
Otto Tschritter,
Hubert Preißl,
Sabine Hopp,
Andreas Fritsche,
Paul-Simon Lievertz,
Arieh Gertler,
Flavien Berthou,
Mohammed Taouis,
Harald Staiger,
Hans-Ulrich Häring,
Anita M. Hennige
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000339060
Subject(s) - insulin , medicine , endocrinology , leptin , insulin receptor , leptin receptor , diabetes mellitus , insulin receptor substrate , irs1 , glycogen synthase , insulin resistance , biology , obesity
Impaired insulin action is an early event in the pathogenesis of obesity and type 2-diabetes, and among the metabolic confounders in obese, hyperleptinaemia is constantly present; however its impact on insulin action in the brain and locomotor activity is unknown.