Open AccessQuercetin Triggers Apoptosis of Lipopolysaccharide (LPS)-induced Osteoclasts and Inhibits Bone Resorption in RAW264.7 Cells
Author(s) -
Chun Guo,
Guoqing Hou,
Xuedong Li,
Xue Xia,
Dongxin Liu,
Dongyang Huang,
Shisuo Du
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000339052
Subject(s) - osteoclast , chemistry , bone resorption , rankl , apoptosis , p38 mitogen activated protein kinases , mapk/erk pathway , viability assay , tumor necrosis factor alpha , microbiology and biotechnology , signal transduction , endocrinology , biology , biochemistry , receptor , activator (genetics)
Quercetin, a flavonoid present in vegetables, has anti-inflammatory properties and potential inhibitory effects on bone resorption. Up to date, the effect of quercetin on lipopolysaccharide (LPS)-induced osteoclastogenesis has not yet been reported. In the current study, we evaluated the effect of quercetin on LPS-induced osteoclast apoptosis and bone resorption.