Quercetin Triggers Apoptosis of Lipopolysaccharide (LPS)-induced Osteoclasts and Inhibits Bone Resorption in RAW264.7 Cells | Zendy

Chun Guo | Zendy; Guoqing Hou | Zendy; Xuedong Li | Zendy; Xue Xia | Zendy; Dongxin Liu | Zendy; Dongyang Huang | Zendy; Shi-xin Du | Zendy

Open Access

Quercetin Triggers Apoptosis of Lipopolysaccharide (LPS)-induced Osteoclasts and Inhibits Bone Resorption in RAW264.7 Cells

Author(s) -

Chun Guo,

Guoqing Hou,

Xuedong Li,

Xue Xia,

Dongxin Liu,

Dongyang Huang,

Shi-xin Du

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000339052

Subject(s) - osteoclast , chemistry , bone resorption , rankl , apoptosis , p38 mitogen activated protein kinases , mapk/erk pathway , viability assay , tumor necrosis factor alpha , microbiology and biotechnology , signal transduction , endocrinology , biology , biochemistry , receptor , activator (genetics)

Quercetin, a flavonoid present in vegetables, has anti-inflammatory properties and potential inhibitory effects on bone resorption. Up to date, the effect of quercetin on lipopolysaccharide (LPS)-induced osteoclastogenesis has not yet been reported. In the current study, we evaluated the effect of quercetin on LPS-induced osteoclast apoptosis and bone resorption.

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