Open AccessHuman Periprostatic Adipose Tissue: its Influence on Prostate Cancer Cells
Author(s) -
Paula Alejandra Sacca,
Virginia Pistone Creydt,
Hosoon Choi,
Osvaldo Mazza,
Sabrina Johanna Fletcher,
Valeria Beatriz Fernández Vallone,
Carlos H. Scorticati,
Norma Alejandra Chasseing,
Juan Calvo
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000339051
Subject(s) - lncap , prostate cancer , adipose tissue , cancer research , hyperplasia , cancer , dihydrotestosterone , androgen , prostate , medicine , endocrinology , hormone
Adipose microenvironment is involved in signaling pathways that influence prostate cancer (PCa) progression. However, the role of human periprostatic adipose tissue (PPAT) from patients with benign prostatic hyperplasia (BPH) has not been studied and compared to that of PPAT from PCa patients. The aim of this paper was to investigate the influence of factors derived from both PPATs on the behavior of androgen-dependent and castration resistant PCa cells.