Open Access4-1BB-mediated Signals Confer Protection Against Folic Acid-induced Nephrotoxicity
Author(s) -
Xiaozhong Li,
Jihong Dai,
Yue Qiu,
Xueguang Zhang
Publication year - 2012
Publication title -
kidney and blood pressure research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1423-0143
pISSN - 1420-4096
DOI - 10.1159/000339022
Subject(s) - nephrotoxicity , immune system , kidney , cd3 , endocrinology , medicine , context (archaeology) , renal function , spleen , creatinine , kidney disease , monoclonal antibody , immunology , antibody , chemistry , biology , cd8 , paleontology
The role of co-stimulatory molecules in renal diseases has been previously examined, however, little is known about the role of 4-1BB in the context of renal diseases resulting from nonimmune-mediated tubulointerstitial fibrosis. Folic acid induced Nephrotoxicity (FAN) in mice was used to explore the role of 4-1BB in this setting.