Open AccessIL-6 Production Stimulated by CD14+Monocytes-paracrined IL-1ß does not Contribute to the Immunosuppressive Activity of Human Umbilical Cord Mesenchymal Stem Cells
Author(s) -
Ding Wang,
Yue Ji,
Ke Chen,
Wei Du,
Yang Zhou,
Zhibo Han,
Ying Cheng,
Lu Liang,
Françis Bayard,
Zhong Chao Han
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000338509
Subject(s) - mesenchymal stem cell , cd14 , secretion , microbiology and biotechnology , umbilical cord , biology , immunology , peripheral blood mononuclear cell , monocyte , cancer research , immune system , endocrinology , in vitro , biochemistry
Human umbilical cord mesenchymal stem cells (hUC-MSCs) possess immunosuppressive activities but the mechanisms of such activities are not fully understood. Here, we investigated the role of IL-6, one of the characteristic factors of MSCs, in the immunoregulating effect of hUC-MSCs on CD4(+) T lymphocytes.