IL-6 Production Stimulated by CD14+Monocytes-paracrined IL-1ß does not Contribute to the Immunosuppressive Activity of Human Umbilical Cord Mesenchymal Stem Cells | Zendy

Ding Wang | Zendy; Yue Ji | Zendy; Ke Chen | Zendy; Wei Du | Zendy; Yang Zhou | Zendy; Zhibo Han | Zendy; Ying Chi | Zendy; Liang Lu | Zendy; Françis Bayard | Zendy; Zhongchao Han | Zendy

Open Access

IL-6 Production Stimulated by CD14⁺Monocytes-paracrined IL-1ß does not Contribute to the Immunosuppressive Activity of Human Umbilical Cord Mesenchymal Stem Cells

Author(s) -

Ding Wang,

Yue Ji,

Ke Chen,

Wei Du,

Yang Zhou,

Zhibo Han,

Ying Chi,

Liang Lu,

Françis Bayard,

Zhongchao Han

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000338509

Subject(s) - mesenchymal stem cell , cd14 , secretion , microbiology and biotechnology , umbilical cord , biology , immunology , peripheral blood mononuclear cell , monocyte , cancer research , immune system , endocrinology , in vitro , biochemistry

Human umbilical cord mesenchymal stem cells (hUC-MSCs) possess immunosuppressive activities but the mechanisms of such activities are not fully understood. Here, we investigated the role of IL-6, one of the characteristic factors of MSCs, in the immunoregulating effect of hUC-MSCs on CD4(+) T lymphocytes.

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