CB1 Cannabinoid Receptor Activation Rescues Amyloid ß-Induced Alterations in Behaviour and Intrinsic Electrophysiological Properties of Rat Hippocampal CA1 Pyramidal Neurones | Zendy

Masoud Haghani | Zendy; Mohammad Shabani | Zendy; Mohammad Javan | Zendy; Fereshteh Motamedi | Zendy; Mahyar Janahmadi | Zendy

Open Access

CB1 Cannabinoid Receptor Activation Rescues Amyloid ß-Induced Alterations in Behaviour and Intrinsic Electrophysiological Properties of Rat Hippocampal CA1 Pyramidal Neurones

Author(s) -

Masoud Haghani,

Mohammad Shabani,

Mohammad Javan,

Fereshteh Motamedi,

Mahyar Janahmadi

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000338494

Subject(s) - hippocampal formation , electrophysiology , neuroscience , cannabinoid receptor , cannabinoid , chemistry , receptor , biology , medicine , agonist

Amyloid beta (Aβ) is believed to be responsible for the synaptic failure that occurs in Alzheimer's disease (AD), but there is little known about the functional impact of Aβ on intrinsic neuronal properties. Here, the cellular effect of Aβ-induced neurotoxicity on the electrophysiological properties of CA1 pyramidal neurons and the mechanism(s) of neuroprotection by CB1 cannabinoid receptor activation was explored.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research