Open AccessCB1 Cannabinoid Receptor Activation Rescues Amyloid ß-Induced Alterations in Behaviour and Intrinsic Electrophysiological Properties of Rat Hippocampal CA1 Pyramidal Neurones
Author(s) -
Masoud Haghani,
Mohammad Shabani,
Mohammad Javan,
Fereshteh Motamedi,
Mahyar Janahmadi
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000338494
Subject(s) - electrophysiology , cannabinoid receptor , neuroscience , neuroprotection , cannabinoid , hippocampal formation , agonist , pyramidal cell , patch clamp , neurotoxicity , hippocampus , chemistry , biology , receptor , medicine , toxicity , biochemistry
Amyloid beta (Aβ) is believed to be responsible for the synaptic failure that occurs in Alzheimer's disease (AD), but there is little known about the functional impact of Aβ on intrinsic neuronal properties. Here, the cellular effect of Aβ-induced neurotoxicity on the electrophysiological properties of CA1 pyramidal neurons and the mechanism(s) of neuroprotection by CB1 cannabinoid receptor activation was explored.