Open AccessLipopolysaccharide-induced Cyclooxygenase-2 Expression in Mouse Transformed Clara Cells
Author(s) -
Rodney D. Britt,
Morgan L. Locy,
Trent E. Tipple,
Leif D. Nelin,
Lynette K. Rogers
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000337602
Subject(s) - chemokine , innate immune system , lipopolysaccharide , immune system , immunology , mapk/erk pathway , population , prostaglandin d2 , inflammation , medicine , biology , microbiology and biotechnology , prostaglandin , signal transduction , environmental health
Exacerbation of innate immune responses can contribute to development of acute lung injury. Multiple cell populations, including the bronchiolar epithelium, coordinate these inflammatory responses. Clara cells, non-ciliated epithelial cells, are located in the distal airways in humans and conducting airways in mice. These cells actively participate in innate immune responses but their precise contributions remain poorly defined.