Open AccessIndomethacin Activates Protein Kinase C and Potentiates α7 ACh Receptor Responses
Author(s) -
Takeshi Kanno,
Takahiro Yaguchi,
Tetsu Nagata,
Tomoyuki Nishizaki
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000337600
Subject(s) - protein kinase c , pharmacology , receptor , microbiology and biotechnology , chemistry , protein kinase a , signal transduction , medicine , kinase , endocrinology , biology
We have earlier found that indomethacin activates CaMKII, as a novel action distinct from COX inhibition. To explore further indomethacin actions, the present study focused upon PKC and examined the effect of indomethacin on α7 ACh receptor responses and hippocampal synaptic transmission through PKC.