Open AccessGranulocyte Colony Stimulating Factor Prevents Kidney Infarction and Attenuates Renovascular Hypertension
Author(s) -
Breno Valentim Nogueira,
Zaira Palomino,
Marcella L. Porto,
Camille M. Balarini,
Thiago de Melo Costa Pereira,
Marcelo Perim Baldo,
Dulce Elena Casarini,
Silvana S. Meyrelles,
Elisardo C. Vasquez
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000337595
Subject(s) - kidney , medicine , endocrinology , ischemia , renal ischemia , granulocyte colony stimulating factor , renovascular hypertension , infarction , reperfusion injury , myocardial infarction , chemotherapy
G-CSF is a critical regulator of hematopoietic cell proliferation, differentiation and survival. It has been reported that G-CSF attenuates renal injury during acute ischemia-reperfusion. In this study we evaluated the effects of G-CSF on the renal and cardiovascular systems of 2K1C hypertensive mice.