Open AccessPPARγ2 Gene Pro12Ala and PPARα Gene Leu162Val Single Nucleotide Polymorphisms Interact with Dietary Intake of Fat in Determination of Plasma Lipid Concentrations
Author(s) -
Aseel AlSaleh,
Gary Frost,
Bruce A. Griffin,
Julie A. Lovegrove,
Susan A. Jebb,
Thomas Sanders,
Sandra D. O’Dell
Publication year - 2011
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000336362
Subject(s) - peroxisome proliferator activated receptor gamma , endocrinology , medicine , peroxisome proliferator activated receptor , single nucleotide polymorphism , lipid metabolism , genotype , cholesterol , apolipoprotein b , biology , chemistry , receptor , gene , biochemistry
The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of lipid metabolism, activated by unsaturated fatty acids. We investigated independent and interactive effects of PPARγ2 gene PPARG Pro12Ala (rs1801282) andPPARαgene PPARA Leu162Val (rs1800206) genotypes with dietary intake of fatty acids on concentrations of plasma lipids in subjects of whom 47.5% had metabolic syndrome.