Open AccessComplete Activation of Thyroid Hormone Receptor β by T<sub>3</sub> is Essential for Normal Cochlear Function and Morphology in Mice
Author(s) -
Claus Peter Richter,
Adrian Münscher,
Danielle S. Machado,
Fredric E. Wondisford,
Tânia Maria Ortiga-Carvalho
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000335812
Subject(s) - tectorial membrane , medicine , endocrinology , thyroid hormone receptor , receptor , activator (genetics) , cochlea , thyroid , chemistry , biology , hormone , triiodothyronine , microbiology and biotechnology , neuroscience
Thyroid hormones (THs) regulate many developmental processes, including the developmental onset of cochlear differentiation and function. TH action is mediated mostly by triiodothyronine (T3) bound to thyroid hormone nuclear receptors (TRs). At positive regulated genes and in the absence of THs, nuclear co-repressors are bound to TRs and decrease basal transcription rate. Ligand (T(3)) binding results in the dissociation of co-repressors and the recruitment of co-activators to the complex, which results in full transcriptional activation.