Open AccessGender Difference in Proteome of Brown Adipose Tissues between Male and Female Rats Exposed to a High Fat Diet
Author(s) -
Duk Kwon Choi,
Tae Seok Oh,
Jung-Won Choi,
Rajib Mukherjee,
Xia Wang,
Hao Líu,
Jong Won Yun
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000335807
Subject(s) - thermogenesis , brown adipose tissue , endocrinology , medicine , sexual dimorphism , proteome , obesity , biology , adipose tissue , sex characteristics , thermogenin , protein expression , adipocyte , bioinformatics , gene , genetics
Although the importance of gender as a key determinant in health and illness has been recognized for a long time, systematic studies of gender differences in medicine are still lacking. We hypothesized that interscapular brown adipocyte tissue (BAT), is not only a key tissue contributing to energy expenditure, but also regulates diet-induced thermogenesis, and may be an ideal target for studying gender differences in obesity development in response to a high fat diet (HFD).