Open AccessAcute Mitochondrial Actions of Glitazones on the Liver: a Crucial Parameter for their Antidiabetic Properties
Author(s) -
María-Nieves Sanz,
Carlos Sánchez-Martín,
Dominique Détaille,
Guillaume Vial,
Michel Rigoulet,
Mohammed-Yehia El-Mir,
Gloria Rodríguez-Villanueva
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000335804
Subject(s) - pioglitazone , rosiglitazone , reactive oxygen species , peroxisome , mitochondrion , oxidative phosphorylation , chemistry , peroxisome proliferator activated receptor , respiratory chain , mitochondrial permeability transition pore , receptor , medicine , endocrinology , pharmacology , biochemistry , biology , microbiology and biotechnology , type 2 diabetes , diabetes mellitus , programmed cell death , apoptosis
Glitazones are synthetic insulin-sensitizing drugs which act as agonists of peroxisome proliferator-activated receptor gamma (PPARγ). However, TZDs action does not exclude independent PPARγ-activation effects. Remarkably, direct mitochondrial action of these agents has not been fully studied yet.