Acute Mitochondrial Actions of Glitazones on the Liver: a Crucial Parameter for their Antidiabetic Properties | Zendy

María-Nieves Sanz | Zendy; Carlos SànchezMartìn | Zendy; Dominique Détaille | Zendy; Guillaume Vial | Zendy; Michel Rigoulet | Zendy; Mohammed-Yehia El-Mir | Zendy; Gloria Rodríguez-Villanueva | Zendy

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Acute Mitochondrial Actions of Glitazones on the Liver: a Crucial Parameter for their Antidiabetic Properties

Author(s) -

María-Nieves Sanz,

Carlos SànchezMartìn,

Dominique Détaille,

Guillaume Vial,

Michel Rigoulet,

Mohammed-Yehia El-Mir,

Gloria Rodríguez-Villanueva

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000335804

Subject(s) - pioglitazone , rosiglitazone , reactive oxygen species , peroxisome , mitochondrion , oxidative phosphorylation , chemistry , peroxisome proliferator activated receptor , respiratory chain , mitochondrial permeability transition pore , receptor , medicine , endocrinology , pharmacology , biochemistry , biology , microbiology and biotechnology , type 2 diabetes , diabetes mellitus , programmed cell death , apoptosis

Glitazones are synthetic insulin-sensitizing drugs which act as agonists of peroxisome proliferator-activated receptor gamma (PPARγ). However, TZDs action does not exclude independent PPARγ-activation effects. Remarkably, direct mitochondrial action of these agents has not been fully studied yet.

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