Open AccessDBZ Blocks LPS-induced Monocyte Activation and Foam Cell Formation via Inhibiting Nuclear Factor-ĸB
Author(s) -
X. C. Xie,
Shixiang Wang,
Lei Xiao,
Jun Zhang,
Jing Wang,
Lina Jin,
Xuji Shen,
Dacheng He,
Xiaohui Zheng,
Yonggong Zhai
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000335760
Subject(s) - monocyte , foam cell , macrophage , inflammation , chemistry , nf κb , microbiology and biotechnology , lipopolysaccharide , cell , pharmacology , signal transduction , biochemistry , endocrinology , immunology , biology , in vitro
It has been widely accepted that chronic inflammation plays important roles in the atherogenesis. Danshensu Bingpian Zhi (DBZ) is a novel synthetic compound derived from the traditional Chinese medicine (TCM) formula Fu Fang Dan Shen (FFDS), which is effective on atherosclerosis clinically. We hypothesized that DBZ possessed the anti-atherosclerosis potentials. Here, we examined the inhibitory effects of DBZ on LPS-induced monocyte activation and foam cell formation.