Increased Expression of Nox1 in Neointimal Smooth Muscle Cells Promotes Activation of Matrix Metalloproteinase-9 | Zendy

Shaoping Xu | Zendy; Amy S. Shriver | Zendy; Dammanahalli K. Jagadeesha | Zendy; Ali H. Chamseddine | Zendy; Katalin Szöcs | Zendy; Neal L. Weintraub | Zendy; Kathy K. Griendling | Zendy; Ramesh C. Bhalla | Zendy; Francis J. Miller | Zendy

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Increased Expression of Nox1 in Neointimal Smooth Muscle Cells Promotes Activation of Matrix Metalloproteinase-9

Author(s) -

Shaoping Xu,

Amy S. Shriver,

Dammanahalli K. Jagadeesha,

Ali H. Chamseddine,

Katalin Szöcs,

Neal L. Weintraub,

Kathy K. Griendling,

Ramesh C. Bhalla,

Francis J. Miller

Publication year - 2012

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000332958

Subject(s) - neointima , nox1 , neointimal hyperplasia , vascular smooth muscle , matrix metalloproteinase , nadph oxidase , reactive oxygen species , chemistry , microbiology and biotechnology , endocrinology , medicine , biology , restenosis , biochemistry , smooth muscle , stent

Vascular injury causes neointimal hypertrophy, which is characterized by redox-mediated matrix degradation and smooth muscle cell (SMC) migration and proliferation. We hypothesized that, as compared to the adjacent medial SMCs, neointimal SMCs produce increased superoxide via NADPH oxidase, which induces redox-sensitive intracellular signaling to activate matrix metalloproteinase-9 (MMP-9).

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