Open AccessNeutrophil Activation in Severe, Early-Onset COPD Patients versus Healthy Non-Smoker Subjects in vitro: Effects of Antioxidant Therapy
Author(s) -
Javier Milara,
Gustavo Alberto San Juan,
Teresa Peiró,
Adela Serrano,
Julio Cortijo
Publication year - 2011
Publication title -
respiration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.264
H-Index - 81
eISSN - 1423-0356
pISSN - 0025-7931
DOI - 10.1159/000332834
Subject(s) - copd , medicine , neutrophil elastase , elastase , immunology , chemotaxis , pathogenesis , reactive oxygen species , acetylcysteine , oxidative stress , inflammation , antioxidant , chemistry , biochemistry , receptor , enzyme
Neutrophils and oxidative stress have been implicated in the pathogenesis of COPD. Severe, early-onset COPD is characterized by a rapid decline in the lung function at an early age; however, nothing is known about neutrophil activation in COPD patients.