Open AccessAmelioration of Albuminuria in ROCK1 Knockout Mice with Streptozotocin-Induced Diabetic Kidney Disease
Author(s) -
Li Zhou,
Fei Liu,
Xiao Ru Huang,
Fang Liu,
Haiyong Chen,
Arther C.K. Chung,
Jianjian Shi,
Lei Wei,
Hui Y. Lan,
Ping Fu
Publication year - 2011
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000332040
Subject(s) - endocrinology , albuminuria , medicine , streptozotocin , kidney , reabsorption , diabetes mellitus
Although blockade of Rho kinase with pharmacologic inhibitors ameliorates renal fibrosis and diabetic kidney disease (DKD), the underlined mechanisms remain largely unclear. The present study tested the hypothesis that ROCK1 may regulate the early development of albuminuria via the megalin/cubilin-dependent mechanism.
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