Open AccessParacrine Interaction between Bone Marrow-derived Stem Cells and Renal Epithelial Cells
Author(s) -
Rafael Soares Lindoso,
Dayana S. Araujo,
Juliana AdãoNovaes,
Rafael M. Mariante,
Karine S. Verdoorn,
Lucianne Fragel-Madeira,
Celso Caruso-Neves,
Rafael Linden,
Adalberto Vieyra,
Marcelo EinickerLamas
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000331739
Subject(s) - paracrine signalling , bone marrow , microbiology and biotechnology , renal stem cell , stem cell , kidney , mesenchymal stem cell , medicine , endocrinology , biology , progenitor cell , receptor
Renal tubular cells are the main target of ischemic insult associated with acute renal injury. Low oxygen and nutrient supplies result in ATP depletion, leading to cell death and loss of renal function. A possible mechanism by which bone marrow-derived cells support renal tissue regeneration relies on the capacity of mononuclear cells (BMMC), particularly mesenchymal stem cells (MSC), to secrete paracrine factors that mediate support for kidney regeneration.