Open AccessStimulation of Murine Intestinal Secretion by Daily Genistein Injections: Gender-dependent Differences
Author(s) -
Layla AlNakkash,
Lyn Batia,
Minoti Bhakta,
Amity Peterson,
Nathan Hale,
Ryan Skinner,
Steven Sears,
J C Jensen
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000331736
Subject(s) - genistein , endocrinology , medicine , basal (medicine) , stimulation , forskolin , secretion , chemistry , insulin
The effect of daily injections with genistein (naturally occurring phytoestrogen) on intestinal chloride (Cl(-)) secretion was measured with Ussing chamber short circuit current (I(sc), μA/cm(2)), in C57BL/6J male and female mice, using 600 mg/kg genistein/day (600G), 300 mg/kg genistein/day (300G), 150 mg/kg genistein/day (150G) or genistein-free vehicle control (0G) for 1- or 2-weeks.