Open AccessCelastrol Inhibits Breast Cancer Cell Invasion via Suppression of NF-ĸB-mediated Matrix Metalloproteinase-9 Expression
Author(s) -
Yoonseo Kim,
Hee-Jun Kang,
Su-Jin Jang,
Jesang Ko
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000331729
Subject(s) - celastrol , cancer research , matrix metalloproteinase , metastasis , nf κb , cell migration , breast cancer , cell culture , cancer cell , mcf 7 , cancer , chemistry , medicine , biology , cell , apoptosis , inflammation , human breast , biochemistry , genetics
Metastasis is one of the main causes of death for patients with malignant tumors. Induction of matrix metalloproteinase (MMP)-9 is particularly important for the invasiveness of various cancer cells. Celastrol, a triterpenoid isolated from the traditional Chinese medicine, is known to inhibit the proliferation of a variety of tumor cells, including leukemia, glioma, prostate and breast cancer cells. In this study, we investigated the effect of celastrol on the migration and invasion of human breast carcinoma cells.