Open AccessCrucial Role of Phospholamban Phosphorylation and S-Nitrosylation in the Negative Lusitropism Induced by 17β-estradiol in the Male Rat Heart
Author(s) -
E. Filice,
Tommaso Angelone,
Ernestina Marianna De Francesco,
Daniela Pellegrino,
Marcello Maggiolini,
Maria Carmela Cerra
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000331712
Subject(s) - phospholamban , gper , endocrinology , medicine , estrogen receptor , enos , estrogen , signal transduction , phosphorylation , nitric oxide , protein kinase a , biology , chemistry , microbiology and biotechnology , nitric oxide synthase , cancer , breast cancer
17β-estradiol (17βE2) plays an important cardiovascular role by activating estrogen receptors (ER) α and ERβ. Previous studies demonstrated that the novel estrogen G protein-coupled receptor (GPR30/GPER) mediates estrogen action in different tissues. We have recently shown in the rat heart that 17βE2 elicits negative inotropism through ERα, ERβ and GPR30, by triggering activation of ERK1/2, phosphatidylinositol 3-kinase (PI3K), protein kinase A (PKA) and endothelial Nitric Oxide synthase (eNOS) signaling.