Open AccessSystemic Heme Oxygenase-1 Transgenic Overexpression Aggravates Pressure Overload-induced Cardiac Hypertrophy in Mice
Author(s) -
Chang Chen,
Rong Hu,
Yan Tong,
Yuchen Sheng,
Huibin Liu,
Xu Gao,
Osamu Nakajima,
Baofeng Yang,
DeLi Dong
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000331710
Subject(s) - pressure overload , medicine , muscle hypertrophy , endocrinology , transgene , calcineurin , genetically modified mouse , heme oxygenase , fibrosis , chemistry , biology , heme , cardiac hypertrophy , transplantation , biochemistry , enzyme , gene
Heme oxygenase-1(HO-1) has been reported to protect against cardiac hypertrophy in cultured neonatal cardiomyocytes treated with HO-1 inducer, cardiac specific HO-1 transgenic mice, or animals treated with HO-1 inducer. The aim of the present study is to examine the effects of systemic HO-1 transgenic overexpression on pressure overload-induced cardiac hypertrophy in mice.