Systemic Heme Oxygenase-1 Transgenic Overexpression Aggravates Pressure Overload-induced Cardiac Hypertrophy in Mice | Zendy

Chang Chen | Zendy; Rong Huo | Zendy; Yan Tong | Zendy; Yue Sheng | Zendy; Huibin Liu | Zendy; Xu Gao | Zendy; Osamu Nakajima | Zendy; Baofeng Yang | Zendy; DeLi Dong | Zendy

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Systemic Heme Oxygenase-1 Transgenic Overexpression Aggravates Pressure Overload-induced Cardiac Hypertrophy in Mice

Author(s) -

Chang Chen,

Rong Huo,

Yan Tong,

Yue Sheng,

Huibin Liu,

Xu Gao,

Osamu Nakajima,

Baofeng Yang,

DeLi Dong

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000331710

Subject(s) - pressure overload , medicine , muscle hypertrophy , endocrinology , transgene , calcineurin , genetically modified mouse , heme oxygenase , fibrosis , chemistry , biology , heme , cardiac hypertrophy , transplantation , biochemistry , enzyme , gene

Heme oxygenase-1(HO-1) has been reported to protect against cardiac hypertrophy in cultured neonatal cardiomyocytes treated with HO-1 inducer, cardiac specific HO-1 transgenic mice, or animals treated with HO-1 inducer. The aim of the present study is to examine the effects of systemic HO-1 transgenic overexpression on pressure overload-induced cardiac hypertrophy in mice.

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