Open AccessThe Cardioprotective Effect of Brief Acidic Reperfusion after Ischemia in Perfused Rat Hearts is not Mimicked by Inhibition of the Na<sup>+</sup>/H<sup>+</sup> Exchanger NHE1
Author(s) -
AnnDorit Andersen,
Bo Hjorth Bentzen,
Henrik K. Salling,
Henrik Klingberg,
Morten Kanneworff,
Morten Grunnet,
Stine Falsig Pedersen
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000331709
Subject(s) - ischemia , cardioprotection , reperfusion injury , intracellular ph , sodium–hydrogen antiporter , chemistry , pharmacology , protein kinase b , medicine , apoptosis , intracellular , biochemistry , sodium , organic chemistry
Ischemic postconditioning (PostC), i.e. brief ischemia-reperfusion cycles before full reperfusion, is protective against cardiac ischemia/reperfusion (I/R) injury. Inhibition of the Na(+)/H(+) exchanger NHE1 and delayed intracellular pH-normalization have been proposed to underlie protection by PostC.