The Cardioprotective Effect of Brief Acidic Reperfusion after Ischemia in Perfused Rat Hearts is not Mimicked by Inhibition of the Na+/H+ Exchanger NHE1 | Zendy

AnnDorit Andersen | Zendy; Bo Hjorth Bentzen | Zendy; Henrik K. Salling | Zendy; Henrik Klingberg | Zendy; Morten Kanneworff | Zendy; Morten Grunnet | Zendy; Stine F. Pedersen | Zendy

Open Access

The Cardioprotective Effect of Brief Acidic Reperfusion after Ischemia in Perfused Rat Hearts is not Mimicked by Inhibition of the Na<sup>+</sup>/H<sup>+</sup> Exchanger NHE1

Author(s) -

AnnDorit Andersen,

Bo Hjorth Bentzen,

Henrik K. Salling,

Henrik Klingberg,

Morten Kanneworff,

Morten Grunnet,

Stine F. Pedersen

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000331709

Subject(s) - ischemia , cardioprotection , reperfusion injury , intracellular ph , sodium–hydrogen antiporter , chemistry , pharmacology , protein kinase b , medicine , apoptosis , intracellular , biochemistry , sodium , organic chemistry

Ischemic postconditioning (PostC), i.e. brief ischemia-reperfusion cycles before full reperfusion, is protective against cardiac ischemia/reperfusion (I/R) injury. Inhibition of the Na(+)/H(+) exchanger NHE1 and delayed intracellular pH-normalization have been proposed to underlie protection by PostC.

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