Thrombospondin-1 Short Hairpin RNA Suppresses Tubulointerstitial Fibrosis in the Kidney of Ureteral Obstruction by Ameliorating Peritubular Capillary Injury | Zendy

Dong Sun | Zendy; Han Ma | Zendy; Hong Xiu Han | Zendy; Zhongcheng Yin | Zendy; Caixia Liu | Zendy; Jinhong Feng | Zendy; Xudong Zhou | Zendy; Xiaoju Li | Zendy; Aiguo Xiao | Zendy; Rong Yu | Zendy

Open Access

Thrombospondin-1 Short Hairpin RNA Suppresses Tubulointerstitial Fibrosis in the Kidney of Ureteral Obstruction by Ameliorating Peritubular Capillary Injury

Author(s) -

Dong Sun,

Han Ma,

Hong Xiu Han,

Zhongcheng Yin,

Caixia Liu,

Jinhong Feng,

Xudong Zhou,

Xiaoju Li,

Aiguo Xiao,

Rong Yu

Publication year - 2011

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000330718

Subject(s) - fibrosis , peritubular capillaries , thrombospondin 1 , small hairpin rna , kidney , vascular endothelial growth factor , endocrinology , ctgf , growth factor , medicine , connective tissue , kidney disease , angiogenesis , pathology , chemistry , rna , receptor , biochemistry , vegf receptors , gene

Thrombospondin-1 (TSP-1), a naturally occurring inhibitor of angiogenesis, is an important mediator of renal fibrosis in clinical and experimental kidney disease. Increasing evidence shows that the microvasculature plays a critical role in progressive renal disease. The present study was undertaken to investigate whether interstitial fibrosis could be prevented by abolishing TSP-1 function in unilateral ureteral obstruction (UUO)-induced renal fibrosis.

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