Open AccessThrombospondin-1 Short Hairpin RNA Suppresses Tubulointerstitial Fibrosis in the Kidney of Ureteral Obstruction by Ameliorating Peritubular Capillary Injury
Author(s) -
Dong Sun,
Yuyuan Ma,
Haegin Han,
Zhongcheng Yin,
Caixia Liu,
Jinhong Feng,
Xudong Zhou,
Xiaoju Li,
Aiguo Xiao,
Rong Yu
Publication year - 2011
Publication title -
kidney and blood pressure research
Language(s) - English
Resource type - Journals
eISSN - 1423-0143
pISSN - 1420-4096
DOI - 10.1159/000330718
Subject(s) - fibrosis , thrombospondin 1 , small hairpin rna , peritubular capillaries , kidney , vascular endothelial growth factor , ctgf , growth factor , connective tissue , endocrinology , medicine , angiogenesis , cancer research , chemistry , pathology , rna , receptor , biochemistry , vegf receptors , gene
Thrombospondin-1 (TSP-1), a naturally occurring inhibitor of angiogenesis, is an important mediator of renal fibrosis in clinical and experimental kidney disease. Increasing evidence shows that the microvasculature plays a critical role in progressive renal disease. The present study was undertaken to investigate whether interstitial fibrosis could be prevented by abolishing TSP-1 function in unilateral ureteral obstruction (UUO)-induced renal fibrosis.