Open AccessRole of Arginase in Impairing Relaxation of Lung Parenchyma of Hyperoxia-Exposed Neonatal Rats
Author(s) -
Nuzhat K.M. Ali,
Anjum Jafri,
Ramadan B Sopi,
Y. S. Prakash,
Richard J. Martin,
Syed I. A. Zaidi
Publication year - 2011
Publication title -
neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.399
H-Index - 84
eISSN - 1661-7819
pISSN - 1661-7800
DOI - 10.1159/000329540
Subject(s) - hyperoxia , arginase , endocrinology , medicine , cyclic guanosine monophosphate , nitric oxide , lung , arginine , chemistry , biochemistry , amino acid
Prolonged exposure of immature lungs to hyperoxia contributes to neonatal lung injury and airway hyperreactivity. We have previously demonstrated that neonatal exposure of rat pups to ≥95% O2 impairs airway relaxation due to disruption of nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling.