Open AccessChange of MAX Interactor 1 Expression in an Anti-Thy1 Nephritis Model and its Effect on Mesangial Cell Proliferation
Author(s) -
Xiaoluan Liu,
Yang Lv,
Yuansheng Xie,
Quan Hong,
Guangyan Cai,
Shujia Zhang,
Wen Li,
Xiangmei Chen
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000327966
Subject(s) - cell growth , mesangial cell , cyclin d1 , cell cycle , cyclin e , cyclin a , cyclin e1 , biology , cyclin dependent kinase 1 , mesangial proliferative glomerulonephritis , cyclin b1 , cyclin , cyclin d , cyclin dependent kinase 2 , microbiology and biotechnology , cancer research , chemistry , cell , endocrinology , glomerulonephritis , kidney , genetics
During the disease process of mesangial proliferative glomerulonephritis, the expression of various factors that influence mesangial proliferation is altered. MAX interactor 1 (Mxi1) antagonizes the transcription factor Myc and is believed to be a tumor suppressor. However, no studies have investigated its effect on mesangial cell proliferation.