Open AccessMechanisms of TGF-β-Induced Differentiation in Human Vascular Smooth Muscle Cells
Author(s) -
YunChi Tang,
Xuehui Yang,
Robert Friesel,
Calvin Vary,
Lucy Liaw
Publication year - 2011
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000327776
Subject(s) - smad , endoglin , r smad , microbiology and biotechnology , receptor , transforming growth factor , vascular smooth muscle , bone morphogenetic protein , biology , bmpr2 , signal transduction , phosphorylation , cellular differentiation , acvrl1 , endocrinology , biochemistry , stem cell , smooth muscle , gene , cd34
Transforming growth factor-β (TGF-β) plays an important role in vascular homeostasis through effects on vascular smooth muscle cells (SMC). Fine-tuning of TGF-β signaling occurs at the level of ALK receptors or Smads, and is regulated with cell type specificity.