Mechanisms of TGF-β-Induced Differentiation in Human Vascular Smooth Muscle Cells | Zendy

Yuefeng Tang | Zendy; Xuehui Yang | Zendy; Robert Friesel | Zendy; Calvin Vary | Zendy; Lucy Liaw | Zendy

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Mechanisms of TGF-β-Induced Differentiation in Human Vascular Smooth Muscle Cells

Author(s) -

Yuefeng Tang,

Xuehui Yang,

Robert Friesel,

Calvin Vary,

Lucy Liaw

Publication year - 2011

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000327776

Subject(s) - smad , endoglin , r smad , microbiology and biotechnology , receptor , transforming growth factor , vascular smooth muscle , bone morphogenetic protein , biology , bmpr2 , signal transduction , phosphorylation , cellular differentiation , acvrl1 , endocrinology , biochemistry , stem cell , smooth muscle , gene , cd34

Transforming growth factor-β (TGF-β) plays an important role in vascular homeostasis through effects on vascular smooth muscle cells (SMC). Fine-tuning of TGF-β signaling occurs at the level of ALK receptors or Smads, and is regulated with cell type specificity.

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