Expression and Effects of IL-33 and ST2 in Allergic Bronchial Asthma: IL-33 Induces Eotaxin Production in Lung Fibroblasts | Zendy

Masatsugu Kurokawa | Zendy; Satoshi Matsukura | Zendy; Mio Kawaguchi | Zendy; Koushi Ieki | Zendy; Shintaro Suzuki | Zendy; Miho Odaka | Zendy; Shin Watanabe | Zendy; Tetsuya Homma | Zendy; Masayuki Sato | Zendy; Munehiro Yamaguchi | Zendy; Hiroko Takeuchi | Zendy; Mitsuru Adachi | Zendy

Open Access

Expression and Effects of IL-33 and ST2 in Allergic Bronchial Asthma: IL-33 Induces Eotaxin Production in Lung Fibroblasts

Author(s) -

Masatsugu Kurokawa,

Satoshi Matsukura,

Mio Kawaguchi,

Koushi Ieki,

Shintaro Suzuki,

Miho Odaka,

Shin Watanabe,

Tetsuya Homma,

Masayuki Sato,

Munehiro Yamaguchi,

Hiroko Takeuchi,

Mitsuru Adachi

Publication year - 2011

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000327259

Subject(s) - eotaxin , immunology , interleukin 33 , ovalbumin , ccl11 , cytokine , allergic inflammation , eosinophil , medicine , lung , interleukin 5 , thymic stromal lymphopoietin , immune system , inflammation , interleukin , asthma

Interleukin (IL)-33, a new member of the IL-1 cytokine family, has been recognized as a key cytokine that enhances T helper 2-balanced immune regulation through its receptor ST2; however, the function and relationship of the IL-33 and ST2 pathways in bronchial asthma are still unclear. We investigated the cellular origin and regulation of IL-33 and ST2 in allergic bronchial asthma in vivo and in vitro.

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