Open AccessNutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis
Author(s) -
Aksam Merched,
Charles N. Serhan,
Lawrence Chan
Publication year - 2011
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000326890
Subject(s) - inflammation , lipid signaling , hyperlipidemia , mediator , endogeny , homeostasis , knockout mouse , biology , chemistry , pharmacology , microbiology and biotechnology , endocrinology , immunology , biochemistry , receptor , diabetes mellitus
Pro-resolving and anti-inflammatory mediator products of murine 12/15-lipoxygenase (LOX) exhibit potent actions on vascular inflammation and protect against the progression of atherosclerosis. The present study was designed to determine whether augmenting dietary lipids modulates the body's endogenous anti-inflammatory pro-resolving mechanisms and promotes atherosclerosis.