Open AccessTransgenic Overexpression of Heart-specific Adenine Nucleotide Translocase 1 Positively Affects Contractile Function in Cardiomyocytes
Author(s) -
Inga Vogelpohl,
Roland Vetter,
Jacqueline Heger,
Linda Ebermann,
Gerhild Euler,
HeinzPeter Schultheiss,
Andrea Dörner
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000325214
Subject(s) - myofibril , biology , medicine , contraction (grammar) , myosin , endocrinology , endoplasmic reticulum , phospholamban , mitochondrion , biochemistry
The adenine nucleotide translocase (ANT) exchanges ATP and ADP over the inner mitochondrial membrane, supplying the cells with energy. Interestingly, myocardial ANT1 overexpression preserves cardiac structure and function under pathophysiological conditions. To ascertain whether the contractile system is directly affected by increased ANT1 expression, we analyzed cell morphology, contraction and relaxation parameters of ANT1 transgenic (ANT1-TG) cardiomyocytes, myofibrillar protein expression, and Ca(2+) handling in ANT1-TG rat hearts.