Open Access<i>In vitro</i> Developed Spontaneously Contracting Cardiomyocytes from Rainbow Trout as a Model System for Human Heart Research
Author(s) -
Bianka Grunow,
Jan Wenzel,
Heinrich Terlau,
Stephanie Langner,
Marina Gebert,
Charli Kruse
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000325212
Subject(s) - rainbow trout , in vitro , electrophysiology , human heart , mammalian heart , microbiology and biotechnology , cell culture , trout , biology , neuroscience , anatomy , fish <actinopterygii> , medicine , biochemistry , fishery , genetics
Cellular models are an interesting tool to study human heart diseases. To date, research groups mainly focus on mouse models, but important murine physiology is different from human characteristics. Recently, scientists found that the electrophysiology of fish cardiomyocytes largely resembles that of humans. So far, cardiomyocyte models were generated using differentiation medium, were stimulated electrically or, when contracting spontaneously, only did so over a short time period. We established an in vitro spontaneously, long-term beating heart model generated from rainbow trout, with the potential to be used as a new human heart model system because of its electrophysiology.