Open AccessAMID Mediates Adenosine-Induced Caspase-Independent HuH-7 Cell Apoptosis
Author(s) -
Dongqin Yang,
Takahiro Yaguchi,
Tetsu Nagata,
Akinobu Gotoh,
Sinisa Dovat,
Chunhua Song,
Tomoyuki Nishizaki
Publication year - 2011
Publication title -
cellular physiology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000325203
Subject(s) - apoptosis , microbiology and biotechnology , tunel assay , adenosine , apoptosis inducing factor , viability assay , programmed cell death , cell , biology , caspase , chemistry , biochemistry
The mechanism underlying extracellular adenosine-induced caspase-independent apoptosis in HuH-7 human hepatoma cells is not fully understood. The present study investigated the role for apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death (AMID) in the pathway.