Open AccessPhenotypic and Differentiation Stability of Human Embryonic Stem Cell-Derived Osteoblasts
Author(s) -
Premjit Arpornmaeklong,
Michael J. Pressler,
Paul H. Krebsbach
Publication year - 2011
Publication title -
cells tissues organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.662
H-Index - 82
ISSN - 1422-6405
DOI - 10.1159/000324831
Subject(s) - embryonic stem cell , biology , microbiology and biotechnology , induced pluripotent stem cell , osteoblast , cellular differentiation , phenotype , cell culture , gene , in vitro , genetics
To ensure the efficiency and safety of transplanted human embryonic stem cell (hESC)-derived osteoblast-like cells (hESC-OS) for bone regeneration, this study was designed to determine the effects of continuous cell expansion on the osteoblastic differentiation stability, pluripotency, and tumorigenic potential of long-term expanded hESC-OS.