Open AccessWhy Does Enamel in <i>Klk4</i>-Null Mice Break above the Dentino-Enamel Junction?
Author(s) -
James P. Simmer,
Yuanyuan Hu,
Amelia S. Richardson,
John D. Bartlett,
Jan C.C. Hu
Publication year - 2011
Publication title -
cells tissues organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.662
H-Index - 82
ISSN - 1422-6405
DOI - 10.1159/000324260
Subject(s) - ameloblast , enamel paint , amelogenin , chemistry , amelogenesis , odontoblast , amelogenesis imperfecta , anatomy , dentin , pathology , biology , dentistry , medicine
The enamel layerof kallikrein 4 (Klk4)-null mice has a normal thickness and a decussating pattern of enamel rods, but it contains residual enamel proteins, is less highly mineralized, and fractures in its deepest part just above the dentino-enamel junction (DEJ). The plane of fracture is puzzling because the deepest enamel is deposited earliest and, through the action of the secretory stage enamel protease (Mmp20), is the most mature part of the enamel layer at the time of the onset of Klk4 expression.
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