Open AccessThe Impact of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Cardiac Fibroblasts Grown under Altered Gravity Conditions
Author(s) -
Claudia Ulbrich,
Annekatrin Leder,
Jessica Pietsch,
Burkhard Flick,
Markus Wehland,
Daniela Grimm
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000323976
Subject(s) - tunel assay , basic fibroblast growth factor , vascular endothelial growth factor , fibroblast growth factor , dapi , apoptosis , endocrinology , growth factor , medicine , extracellular matrix , biology , chemistry , microbiology and biotechnology , biochemistry , receptor , vegf receptors
Myocardium is very sensitive to gravitational changes. During a spaceflight cardiovascular atrophy paired with rhythm problems and orthostatic intolerance can occur. The aim of this study was to investigate the impact of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on cardiac fibroblasts (CF) grown under altered gravity conditions.