Open Accessp38 MAPK Contributes to the Growth Inhibition of Leukemic Tumor Cells Mediated by Human Umbilical Cord Mesenchymal Stem Cells
Author(s) -
Kun Tian,
Shaoguang Yang,
Qian Ren,
Zhibo Han,
Shihong Lu,
Fen Ma,
Lei Zhang,
Zhongchao Han
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000323973
Subject(s) - mesenchymal stem cell , umbilical cord , stem cell , cancer research , microbiology and biotechnology , mapk/erk pathway , p38 mitogen activated protein kinases , cord lining , medicine , biology , immunology , adult stem cell , kinase , endothelial stem cell , in vitro , biochemistry
Mesenchymal stem cells (MSCs) have been implicated in antitumor therapy for hematopoietic and non-hematopoietic tumors. Cell-contact and soluble factors are demonstrated to play a role in the growth inhibition of tumor cells mediated by MSCs in vitro, while there is little clue about signaling pathways involved in the process. P38 MAPK has been implicated as a suppressor of cell proliferation and tumorigenesis. We here investigate whether p38 MAPK is involved in MSC-induced growth inhibition of leukemic tumor cells.