Impaired Stimulatory Effect of ETB Receptor on D3 Receptor in Immortalized Renal Proximal Tubule Cells of Spontaneously Hypertensive Rats | Zendy

Ye Zhang | Zendy; Chunjiang Fu | Zendy; Hongmei Ren | Zendy; Duofen He | Zendy; Xukai Wang | Zendy; Laureano D. Asico | Zendy; Pedro A. José | Zendy; Chunyu Zeng | Zendy

Open Access

Impaired Stimulatory Effect of ETB Receptor on D<sub>3</sub> Receptor in Immortalized Renal Proximal Tubule Cells of Spontaneously Hypertensive Rats

Author(s) -

Ye Zhang,

Chunjiang Fu,

Hongmei Ren,

Duofen He,

Xukai Wang,

Laureano D. Asico,

Pedro A. José,

Chunyu Zeng

Publication year - 2011

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000323135

Subject(s) - endocrinology , medicine , receptor , agonist , chemistry , natriuresis , receptor antagonist , kidney , antagonist

Activation of renal D₃ receptor induces natriuresis and diuresis in Wistar-Kyoto (WKY) rats; in the presence of ETB receptor antagonist, the natriuretic effect of D₃ receptor in WKY rats is reduced. We hypothesize that ETB receptor activation may regulate D₃ receptor expression in renal proximal tubule (RPT) cells from WKY rats, which is impaired in RPT cells from spontaneously hypertensive rats (SHRs).

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