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Activation of renal D₃ receptor induces natriuresis and diuresis in Wistar-Kyoto (WKY) rats; in the presence of ETB receptor antagonist, the natriuretic effect of D₃ receptor in WKY rats is reduced. We hypothesize that ETB receptor activation may regulate D₃ receptor expression in renal proximal tubule (RPT) cells from WKY rats, which is impaired in RPT cells from spontaneously hypertensive rats (SHRs).

kidney and blood pressure research

Impaired Stimulatory Effect of ETB Receptor on D&lt;sub&gt;3&lt;/sub&gt; Receptor in Immortalized Renal Proximal Tubule Cells of Spontaneously Hypertensive Rats