Open AccessLipopolysaccharide Increases Plasma Levels of Corticotropin-Releasing Hormone in Rats
Author(s) -
Miriam Goebel,
Andreas Stengel,
Lixin Wang,
Joseph R. Reeve,
Yvette Taché
Publication year - 2010
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000322590
Subject(s) - medicine , endocrinology , corticotropin releasing hormone , radioimmunoassay , lipopolysaccharide , adrenocorticotropic hormone , chemistry , basal (medicine) , hormone , peptide hormone , hypothalamus , insulin
Corticotropin-releasing hormone (CRH) is expressed in the brain, immune cells and the gut, where gene expression is upregulated by lipopolysaccharide (LPS) 6 h after injection. Whether these changes are reflected by increased circulating levels of CRH and adrenocorticotropic hormone (ACTH) is unknown.