Open AccessEarly Phase of Allergic Airway Inflammation in Diabetic Rats: Role of Insulin on the Signaling Pathways and Mediators
Author(s) -
Joilson O. Martins,
Beatriz M Wittlin,
Denise B.C. Anger,
Daniel O. T. A. Martins,
Paulina Sannomiya,
Sônia Jancar
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000322341
Subject(s) - medicine , endocrinology , nitric oxide synthase , inflammation , ovalbumin , bronchoalveolar lavage , protein kinase b , nitric oxide , signal transduction , allergic inflammation , chemistry , immunology , lung , immune system , biochemistry
Allergic lung inflammation is impaired in diabetic rats and is restored by insulin treatment. In the present study we investigated the effect of insulin on the signaling pathways triggered by allergic inflammation in the lung and the release of selected mediators.