Open AccessEpigallocatechin-3 Gallate, a Green Tea Catechin, Attenuated the Downregulation of the Cardiac Gap Junction Induced by High Glucose in Neonatal Rat Cardiomyocytes
Author(s) -
Yu Lu,
Yanbo Zhao,
Youqi Fan,
Min Wang,
Shengjie Xu,
Guosheng Fu
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000320564
Subject(s) - mapk/erk pathway , western blot , downregulation and upregulation , p38 mitogen activated protein kinases , epigallocatechin gallate , gap junction , catechin , chemistry , connexin , kinase , protein kinase a , microbiology and biotechnology , medicine , endocrinology , biology , biochemistry , antioxidant , gene , polyphenol , intracellular
The remodeling of cardiac gap junctions has been postulated to contribute to the arrhythmias in a diabetic heart. Epigallocatechin-3 gallate (EGCG), a green tea catechin, has recently been recognized for its protection in cardiovascular disease. This study investigated the effect of EGCG on the possible remodeling of gap junctions under high glucose in cultured neonatal rat cardiomyocytes.