Open AccessGH3B6 Pituitary Tumor Cell Proliferation is Mediated by PKCα and PKCε via ERK 1/2-dependent Pathway
Author(s) -
Juan Pablo Petiti,
Silvina Gutiérrez,
Ana Lucía De Paul,
Verónica Andreoli,
Claudia Mariela Palmeri,
Liliana del Valle Sosa,
José Luis Bocco,
Alicia Inés Torres
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000320519
Subject(s) - protein kinase c , cell growth , protein kinase b , cell cycle , microbiology and biotechnology , mapk/erk pathway , phorbol , biology , phosphorylation , chemistry , cell , biochemistry
In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated.