Open AccessOsteopontin Overproduction Is Associated with Progression of Glomerular Fibrosis in a Rat Model of Anti-Glomerular Basement Membrane Glomerulonephritis
Author(s) -
Justin Merszei,
Jean Wu,
Lisa Torres,
John Hicks,
Todd Bartkowiak,
Filemon K. Tan,
Yahuan Lou
Publication year - 2010
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000319238
Subject(s) - fibrosis , osteopontin , glomerular basement membrane , extracellular matrix , glomerulonephritis , pathology , myofibroblast , biology , microbiology and biotechnology , medicine , immunology , kidney , endocrinology
Glomerular fibrosis is the common end result of glomerulonephritis (GN) regardless of etiology. In our rat model for anti-glomerular basement membrane GN, severe fibrosis follows glomerular inflammation. We investigated the association between expression of extracellular matrix (ECM) proteins and progression of glomerular fibrosis.