Osteopontin Overproduction Is Associated with Progression of Glomerular Fibrosis in a Rat Model of Anti-Glomerular Basement Membrane Glomerulonephritis | Zendy

Justin Merszei | Zendy; Jean Wu | Zendy; Lisa K. Torres | Zendy; John M. Hicks | Zendy; Todd Bartkowiak | Zendy; Filemon K. Tan | Zendy; YaHuan Lou | Zendy

Open Access

Osteopontin Overproduction Is Associated with Progression of Glomerular Fibrosis in a Rat Model of Anti-Glomerular Basement Membrane Glomerulonephritis

Author(s) -

Justin Merszei,

Jean Wu,

Lisa K. Torres,

John M. Hicks,

Todd Bartkowiak,

Filemon K. Tan,

YaHuan Lou

Publication year - 2010

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000319238

Subject(s) - fibrosis , osteopontin , glomerular basement membrane , extracellular matrix , glomerulonephritis , pathology , myofibroblast , biology , microbiology and biotechnology , medicine , immunology , kidney , endocrinology

Glomerular fibrosis is the common end result of glomerulonephritis (GN) regardless of etiology. In our rat model for anti-glomerular basement membrane GN, severe fibrosis follows glomerular inflammation. We investigated the association between expression of extracellular matrix (ECM) proteins and progression of glomerular fibrosis.

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