Open AccessVariants of the Adenosine A<sub>2A</sub> Receptor Gene Are Protective against Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes
Author(s) -
Bashira A. Charles,
Yvette P. Conley,
Guanjie Chen,
Rachel G. Miller,
Janice S. Dorman,
Michael B. Gorin,
Robert E. Ferrell,
Susan M. Sereika,
Charles N. Rotimi,
Trevor J. Orchard
Publication year - 2010
Publication title -
ophthalmic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 54
eISSN - 1423-0259
pISSN - 0030-3747
DOI - 10.1159/000317057
Subject(s) - single nucleotide polymorphism , medicine , diabetic retinopathy , haplotype , odds ratio , type 1 diabetes , type 2 diabetes , hazard ratio , diabetes mellitus , allele , endocrinology , genotype , biology , genetics , confidence interval , gene
The adenosine A(2A) receptor (ADORA(2A)) may ameliorate deleterious physiologic effects associated with tissue injury in individuals with diabetes. We explored associations between variants of the ADORA(2A) gene and proliferative diabetic retinopathy (PDR) in a cohort of patients with type 1 diabetes (T1D).