Variants of the Adenosine A2A Receptor Gene Are Protective against Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes | Zendy

Bashira A. Charles | Zendy; Yvette P. Conley | Zendy; Guanjie Chen | Zendy; Rachel G. Miller | Zendy; Janice S. Dorman | Zendy; Michael B. Gorin | Zendy; Robert E. Ferrell | Zendy; Susan M. Sereika | Zendy; Charles N. Rotimi | Zendy; Trevor J. Orchard | Zendy

Open Access

Variants of the Adenosine A<sub>2A</sub> Receptor Gene Are Protective against Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes

Author(s) -

Bashira A. Charles,

Yvette P. Conley,

Guanjie Chen,

Rachel G. Miller,

Janice S. Dorman,

Michael B. Gorin,

Robert E. Ferrell,

Susan M. Sereika,

Charles N. Rotimi,

Trevor J. Orchard

Publication year - 2010

Publication title -

ophthalmic research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 54

eISSN - 1423-0259

pISSN - 0030-3747

DOI - 10.1159/000317057

Subject(s) - single nucleotide polymorphism , medicine , diabetic retinopathy , haplotype , odds ratio , type 1 diabetes , type 2 diabetes , hazard ratio , diabetes mellitus , allele , endocrinology , genotype , biology , genetics , confidence interval , gene

The adenosine A(2A) receptor (ADORA(2A)) may ameliorate deleterious physiologic effects associated with tissue injury in individuals with diabetes. We explored associations between variants of the ADORA(2A) gene and proliferative diabetic retinopathy (PDR) in a cohort of patients with type 1 diabetes (T1D).

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