Phosphorylation of the Immunomodulator FTY720 Inhibits Programmed Cell Death of Fibroblasts Via the S1P3 Receptor Subtype and Bcl-2 Activation | Zendy

Henrik Potteck | Zendy; Barbara Nieuwenhuis | Zendy; Anja Lüth | Zendy; Markus van der Giet | Zendy; Burkhard Kleuser | Zendy

Open Access

Phosphorylation of the Immunomodulator FTY720 Inhibits Programmed Cell Death of Fibroblasts Via the S1P<sub>3</sub> Receptor Subtype and Bcl-2 Activation

Author(s) -

Henrik Potteck,

Barbara Nieuwenhuis,

Anja Lüth,

Markus van der Giet,

Burkhard Kleuser

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000315107

Subject(s) - phosphorylation , sphingosine , microbiology and biotechnology , apoptosis , programmed cell death , pi3k/akt/mtor pathway , protein kinase b , biology , kinase , sphingosine 1 phosphate , signal transduction , receptor , sphingosine kinase , biochemistry

FTY720, a synthetic compound produced by modification of a metabolite from Isaria sinclairii, is known as a unique immunosuppressive agent that exerts its activity by inhibiting lymphocyte egress from secondary lymphoid tissues. FTY720 is phosphorylated in vivo by sphingosine kinase 2 to FTY720-phosphate (FTY720-P), which acts as a potent sphingosine-1-phosphate (S1P) receptor agonist. Despite its homology to S1P, which exerts antiapoptotic actions in different cells, FTY720 has also been reported to be able to induce apoptosis in a variety of cells.

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