Open AccessPhosphorylation of the Immunomodulator FTY720 Inhibits Programmed Cell Death of Fibroblasts Via the S1P<sub>3</sub> Receptor Subtype and Bcl-2 Activation
Author(s) -
Henrik Potteck,
Barbara Nieuwenhuis,
Anja Lüth,
Markus van der Giet,
Burkhard Kleuser
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000315107
Subject(s) - phosphorylation , sphingosine , microbiology and biotechnology , apoptosis , programmed cell death , pi3k/akt/mtor pathway , protein kinase b , biology , kinase , sphingosine 1 phosphate , signal transduction , receptor , sphingosine kinase , biochemistry
FTY720, a synthetic compound produced by modification of a metabolite from Isaria sinclairii, is known as a unique immunosuppressive agent that exerts its activity by inhibiting lymphocyte egress from secondary lymphoid tissues. FTY720 is phosphorylated in vivo by sphingosine kinase 2 to FTY720-phosphate (FTY720-P), which acts as a potent sphingosine-1-phosphate (S1P) receptor agonist. Despite its homology to S1P, which exerts antiapoptotic actions in different cells, FTY720 has also been reported to be able to induce apoptosis in a variety of cells.