Open AccessDeficiency in the Serum-Derived Hyaluronan-Associated Protein-Hyaluronan Complex Enhances Airway Hyperresponsiveness in a Murine Model of Asthma
Author(s) -
Long Zhu,
Lisheng Zhuo,
Koji Kimata,
Etsuro Yamaguchi,
Hideto Watanabe,
Mark A. Aronica,
Vincent C. Hascall,
Kenji Baba
Publication year - 2010
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000314362
Subject(s) - ovalbumin , bronchoalveolar lavage , immunology , methacholine , medicine , bronchial hyperresponsiveness , lung , endocrinology , respiratory disease , immune system
Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is also involved in airway allergy.